منابع مشابه
Dopaminergic neurons differentiating from LRRK2 G2019S induced pluripotent stem cells show early neuritic branching defects
Some mutations of the LRRK2 gene underlie autosomal dominant form of Parkinson's disease (PD). The G2019S is a common mutation that accounts for about 2% of PD cases. To understand the pathophysiology of this mutation and its possible developmental implications, we developed an in vitro assay to model PD with human induced pluripotent stem cells (hiPSCs) reprogrammed from skin fibroblasts of PD...
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The transcription factor GATA6 is expressed in the fetal pulmonary epithelium of the developing mouse lung and loss of function studies strongly suggested that it is required for proper branching morphogenesis and epithelial differentiation. We have further investigated the role of GATA6 in this process by utilizing a pulmonary epithelium specific promoter to maintain high levels of GATA6 prote...
متن کاملGGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function.
Microsatellite expansions are the leading cause of numerous neurodegenerative disorders. Here we demonstrate that GGGGCC and CAG microsatellite repeat RNAs associated with C9orf72 in amyotrophic lateral sclerosis/frontotemporal dementia and with polyglutamine diseases, respectively, localize to neuritic granules that undergo active transport into distal neuritic segments. In cultured mammalian ...
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Type I lissencephaly results from mutations in the doublecortin (DCX) and LIS1 genes. We generated Dcx knockout mice to further understand the pathophysiological mechanisms associated with this cortical malformation. Dcx is expressed in migrating interneurons in developing human and mouse brains. Video microscopy analyses of such tangentially migrating neuron populations derived from the medial...
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We illustrate the importance of branching in planning by exploring alternative branching schemes in Graphplan. As argued elsewhere, Graphplan can be understood as a heuristic search planner that performs an IDA* regression search with a heuristic function encoded in the plan graph. Here, we study two alternatives to Graphplan where the IDA* search algorithm and the heuristic encoded in the plan...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2007
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc2134